カマチグループ 東京品川病院

EN
アクセス アクセス

治験開発・研究センター

研究実績（論文）

2023年

  • Shinkai M, Katsumata N, Kawai S, Kuyama S, Sasaki O, Yanagita Y, Yoshida M, Uneda S, Tsuji Y, Harada H, Nishida Y, Sakamoto Y, Himeji D, Arioka H, Sato K, Katsuki R, Shomura H, Nakano H, Ohtani H, Sasaki K, Adachi T. Phase III study of bilayer sustained-release tramadol tablets in patients with cancer pain: a double-blind parallel-group, non-inferiority study with immediate-release tramadol capsules as an active comparator. Support Care Cancer. 2023 Dec 29;32(1):69.
  • Shinkai M, Yabuta T. Tezepelumab: an anti-thymic stromal lymphopoietin monoclonal antibody for the treatment of asthma. Immunotherapy. 2023 Dec;15(17):1435-1447.
  • Iwata S, Kobayashi O, Kurashima K, Doi Y, Kunishima H, Shinkai M, Tsushima K, Yamato M, Kano A, Hibino M, Yamatake T, Sakurai T, Ogura T. Findings from a discontinued clinical trial of favipiravir in high-risk patients with early-onset COVID-19. J Infect Chemother. 2023 Oct 12:S1341-321X(23)00255-6.
  • Martinez FJ, Criner GJ, Gessner C, Jandl M, Scherbovsky F, Shinkai M, Siler TM, Vogelmeier CF, Voves R, Wedzicha JA, Bartels C, Bottoli I, Byiers S, Cardenas P, Eckert JH, Gutzwiller FS, Knorr B, Kothari M, Parlikar R, Tanase AM, Franssen FME. Icenticaftor, a CFTR Potentiator, in COPD: A Multicenter, Parallel-Group, Double-Blind Clinical Trial. Am J Respir Crit Care Med. 2023 Aug 15;208(4):417-427.
  • Onodera T, Sax N, Sato T, Adachi Y, Kotaki R, Inoue T, Shinnakasu R, Nakagawa T, Fukushi S, Terooatea T, Yoshikawa M, Tonouchi K, Nagakura T, Moriyama S, Matsumura T, Isogawa M, Terahara K, Takano T, Sun L, Nishiyama A, Omoto S, Shinkai M, Kurosaki T, Yamashita K, Takahashi Y. CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes. Sci Adv. 2023 Jun 16;9(24):
  • Shinoda M, Ota S, Yoshida Y, Hirouchi T, Shinada K, Sato T, Morikawa M, Ishii N, Shinkai M. High Fever, Wide Distribution of Viral Pneumonia, and Pleural Effusion are More Critical Findings at the First Visit in Predicting the Prognosis of COVID-19: A Single Center, retrospective, Propensity Score-Matched Case-Control Study. Int J Gen Med. 2023 Jun 8;16:2337-2348.
  • Tomohiro Takano, Takashi Sato, Ryutaro Kotaki, Saya Moriyama, Shuetsu Fukushi, Masahiro Shinoda, Kiyomi Kabasawa, Nagashige Shimada, Mio Kousaka, Yu Adachi, Taishi Onodera, Kazutaka Terahara, Masanori Isogawa, Takayuki Matsumura, Masaharu Shinkai*, Yoshimasa Takahashi*. Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain. Nat Commun. 2023 Mar 15;14(1):1451.
  • Miyamoto S, Arashiro T, Ueno A, Kanno T, Saito S, Katano H, Iida S, Ainai A, Ozono S, Hemmi T, Hirata Y, Moriyama S, Kotaki R, Kinoshita H, Yamada S, Shinkai M, Fukushi S, Takahashi Y, Suzuki T. Non-Omicron breakthrough infection with higher viral load and longer vaccination-infection interval improves SARS-CoV-2 BA.4/5 neutralization. iScience. 2023 Feb 17;26(2):105969. doi: 10.1016/j.isci.2023.105969. Epub 2023 Jan 13.
  • Shimada N, Shinoda M, Takei H, Yoshida Y, Nishimura M, Kousaka M, Morikawa M, Sato T, Matsuse H, Shinkai M. A case of reinfection with a different variant of SARS-CoV-2: case report. Egypt J Intern Med. 2023;35(1):13. doi: 10.1186/s43162-023-00194-4. Epub 2023 Feb 8.
  • Kimura Y, Shinoda M, Shinkai M, Kaneko T. Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells. PeerJ. 2023 Jan 17;11:e14695.

2022年

  • Takuhiro Sonoyama, Satoshi Iwata, Masaharu Shinkai, Naoko Iwata-Yoshikawa, Nozomi Shiwa-Sudo, Takuya Hemmi, Akira Ainai, Noriyo Nagata, Nobuaki Matsunaga, Yukio Tada, Tomoyuki Homma, Shinya Omoto, Risa Yokokawa Shibata, Kenji Igarashi, Tadaki Suzuki, Hideki Hasegawa, Mari Ariyasu. Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults. Vaccine 2022 Dec 16; S0264-410X(22):4328-4333.
  • Fujii H, Nagakura H, Kobayashi N, Kubo S, Tanaka K, Watanabe K, Horita N, Hara Y, Nishikawa M, Miura K, Koizumi H, Ito Y, Tsubakihara M, Miyazawa N, Kudo M, Shinkai M, Kaneko T. Liquid biopsy for detecting epidermal growth factor receptor mutation among patients with non-small cell lung cancer treated with afatinib: a multicenter prospective study. BMC Cancer. 2022 Oct 4;22(1):1035. 
  • Kinoshita T, Shinoda M, Nishizaki Y, Shiraki K, Hirai Y, Kichikawa Y, Tsushima K, Shinkai M, Komura N, Yoshida K, Kido Y, Kakeya H, Uemura N, Kadota J. A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study). BMC Med. 2022 Sep 27;20(1):342.
  • Terahara K, Sato T, Adachi Y, Tonouchi K, Onodera T, Moriyama S, Sun L, Takano T, Nishiyama A, Kawana-Tachikawa A, Matano T, Matsumura T, Shinkai M, Isogawa M, Takahashi Y. SARS-CoV-2-specific CD4+ T cell longevity correlates with Th17-like phenotype. iScience. 2022 Sep 16;25(9):104959.
  • Shinkai M, Sonoyama T, Kamitani A, Shibata RY, Seki NM, Omoto S, Shinoda M, Sato T, Ishii N, Igarashi K, Ariyasu M. Immunogenicity and safety of booster dose of S-268019-b or BNT162b2 in Japanese participants: An interim report of phase 2/3, randomized, observer-blinded, noninferiority study. Vaccine. 2022 Jul 30;40(32):4328-4333.
  • Shinkai M, Ebisawa M, Fukushima Y, Takeuchi S, Okada H, Tokiyo T, Hayashi N, Takikawa M, Colice G, Almqvist G. One-year safety and tolerability of tezepelumab in Japanese patients with severe uncontrolled asthma: results of the NOZOMI study. J Asthma. 2022 Jun 16:1-9.
  • Nishimura M, Sugawa S, Ota S, Suematsu E, Shinoda M, Shinkai M. Detection of silent infection of severe acute respiratory syndrome coronavirus 2 by serological tests. PLoS One. 2022 May 20; 17(5):e0267566.
  • Takano T, Morikawa M, Adachi Y, Kabasawa K, Sax N, Moriyama S, Sun L, Isogawa M, Nishiyama A, Onodera T, Terahara K, Tonouchi K, Nishimura M, Tomii K, Yamashita K, Matsumura T, Shinkai M, Takahashi Y. Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine. Cell Rep Med. 2022 May 17; 3(5):100631.
  • Kotaki R, Adachi Y, Moriyama S, Onodera T, Fukushi S, Nagakura T, Tonouchi K, Terahara K, Sun L, Takano T, Nishiyama A, Shinkai M, Oba K, Nakamura-Uchiyama F, Shimizu H, Suzuki T, Matsumura T, Isogawa M, Takahashi Y. SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine.Sci Immunol. 2022 Apr 22; 7(70):eabn8590.
  • Shinada K, Sato T, Moriyama S, Adachi Y, Shinoda M, Ota S, Morikawa M, Mineshita M, Matsumura T, Takahashi Y, Shinkai M. Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir. Viruses. 2022 Mar 24; 14(4):670.

2021年

  • Shinoda M, Shinkai M, Hara Y, Tomaru K, Manabe S, Murakami S, Saito H, Kobayashi N, Miyazawa N, Nishikawa M, Kaneko T.
    Efficacy and safety of carboplatin and pemetrexed followed by maintenance with pemetrexed for elderly patients with advanced non-squamous non-small cell lung cancer: A single-arm, open-label, multicenter, phase II study. Asia Pac J Clin Oncol.
    2021 Dec;17(6):486-494.
  • Kei Miyakawa, Sousuke Kubo, Sundararaj Stanleyraj Jeremiah, Hirofumi Go, Yutaro Yamaoka, Norihisa Ohtake, Hideaki Kato, Satoshi Ikeda, Takahiro Mihara, Ikuro Matsuba, Naoko Sanno, Masaaki Miyakawa, Masaharu Shinkai, Tomoyuki Miyazaki, Takashi Ogura, Shuichi Ito, Takeshi Kaneko, Kouji Yamamoto, Atsushi Goto, Akihide Ryo.　Persistence of robust humoral immune response in COVID-19 convalescent individuals over twelve months after infection: Open Forum Infect Dis. 2021 Dec 10.
  • Ryo Shinnakasu, Shuhei Sakakibara, Hiromi Yamamoto, Po-hung Wang, Saya Moriyama, Nicolas Sax, Chikako Ono, Atsushi Yamanaka, Yu Adachi, Taishi Onodera, Takashi Sato, Masaharu Shinkai, Ryosuke Suzuki, Yoshiharu Matsuura, Noritaka Hashii, Yoshimasa Takahashi, Takeshi Inoue, Kazuo Yamashita, Tomohiro Kurosaki. Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses: J Exp Med. 2021 Dec 6; 218(12): e20211003.
  • Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E. Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki. Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients. J Exp Med. 2021 Dec 6; 218(12): e20211327.
  • Shinoda M, Shinkai M, Hara Y, Tomaru K, Manabe S, Murakami S, Saito H, Kobayashi N, Miyazawa N, Nishikawa M, Kaneko T. Efficacy and safety of carboplatin and pemetrexed followed by maintenance with pemetrexed for elderly patients with advanced non-squamous non-small cell lung cancer: A single-arm, open-label, multicenter, phase II study. Asia Pac J Clin Oncol. 2021 Dec;17(6):486-494.
  • Shindo Y, Kondoh Y, Kada A, Doi Y, Tomii K, Mukae H, Murata N, Imai R, Okamoto M, Yamano Y, Miyazaki Y, Shinoda M, Aso H, Izumi S, Ishii H, Ito R, Saito AM, Saito TI, Hasegawa Y. Phase II Clinical Trial of Combination Therapy with Favipiravir and Methylprednisolone for COVID-19 with Non-Critical Respiratory Failure. Infect Dis Ther. 2021 Dec;10(4):2353-2369.
  • Niimi A, Saito J, Kamei T, Shinkai M, Ishihara H, Machida M, Miyazaki S. Randomised trial of the P2X3 receptor antagonist sivopixant for refractory chronic cough. Eur Respir J. 2021 Oct 14:2100725.
  • Masashi Nishimura, Shinichiro Ota, Sumitaka Yamanaka, Kanako Shinada, Masaharu Shinkai An intrathoracic giant tumour and vanishing lung cyst after tumour resection. Respirol Case Rep. 2021 Oct; 9(10): e0848.
  • Shinichiro Ota, Satoshi Sugawa, Etsuko Suematsu, Masahiro Shinoda, Masahiko Izumizaki, Masaharu Shinkai. Possibility of underestimation of COVID-19 prevalence by PCR and serological tests. J Microbiol Immunol Infect. 2021 Sep 29
  • Masaharu Shinkai, Kenji Tsushima, Shingo Tanaka, Eri Hagiwara, Norihito Tarumoto, Ichiro Kawada, Yuji Hirai, Sho Fujiwara, Yuko Komase, Takeshi Saraya, Hidefumi Koh, Naho Kagiyama, Megumi Shimada, Daiki Kanou, Shinichi Antoku, Yujiro Uchida, Yutaka Tokue, Mikio Takamori, Yasuhiro Gon, Kenya Ie, Yoshitaka Yamazaki, Kazumasa Harada, Naoki Miyao, Takashi Naka, Mitsunaga Iwata, Atsushi Nakagawa, Kazutoshi Hiyama, Yoshihiko Ogawa, Masahiro Shinoda, Shinichiro Ota, Takatomo Hirouchi, Jiro Terada, Shuichi Kawano, Takashi Ogura, Tsutomu Sakurai, Yoshihiko Matsumoto, Hiroyuki Kunishima, Osamu Kobayashi, Satoshi Iwata. Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial Infect Dis Ther. 2021 Dec; 10(4): 2489–2509. Published online 2021 Aug 27
  • Saya Moriyama, Yu Adachi, Takashi Sato, Keisuke Tonouchi, Lin Sun, Shuetsu Fukushi, Souichi Yamada, Hitomi Kinoshita, Kiyoko Nojima, Takayuki Kanno, Minoru Tobiume, Keita Ishijima, Yudai Kuroda, Eun-Sil Park, Taishi Onodera, Takayuki Matsumura, Tomohiro Takano, Kazutaka Terahara, Masanori Isogawa, Ayae Nishiyama, Ai Kawana-Tachikawa, Masaharu Shinkai, Natsuo Tachikawa, Shigeki Nakamura, Takahiro Okai, Kazu Okuma, Tetsuro Matano, Tsuguto Fujimoto, Ken Maeda, Makoto Ohnishi, Takaji Wakita, Tadaki Suzuki, Yoshimasa Takahashi. Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants. Immunity. 2021 Aug 10; 54(8): 1841–1852.e4.
  • Mukae H, Kaneko T, Obase Y, Shinkai M, Katsunuma T, Takeyama K, Terada J, Niimi A, Matsuse H, Yatera K, Yamamoto Y, Azuma A, Arakawa H, Iwanaga T, Ogawa H, Kurahashi K, Gon Y, Sakamoto H, Shibata Y, Tamada T, Nishioka Y, Haranaga S, Fujieda S, Miyashita N, Mochizuki H, Yokoyama A, Yoshihara S, Tamaoki J; JRS guidelines committee for the management of cough and sputum. The Japanese respiratory society guidelines for the management of cough and sputum (digest edition). Respir Investig. 2021 May;59(3):270-290.
  • Sumitaka Yamanaka, Shinichiro Ota, Yukihiro Yoshida, Masaharu Shinkai. COVID‐19 pneumonia and an indelible ground‐glass nodule. Respirol Case Rep. 2021 May; 9(5): e00751.
  • Satoshi Ikeda, Toshihiro Misumi, Shinyu Izumi, Keita Sakamoto, Naoki Nishimura, Shosei Ro, Koichi Fukunaga, Satoshi Okamori, Natsuo Tachikawa, Nobuyuki Miyata, Masaharu Shinkai, Masahiro Shinoda, Yasunari Miyazaki, Yuki Iijima, Takehiro Izumo, Minoru Inomata, Masaki Okamoto, Tomoyoshi Yamaguchi, Keisuke Iwabuchi, Makoto Masuda, Hiroyuki Takoi, Yoshitaka Oyamada, Shigeki Fujitani, Masamichi Mineshita, Haruyuki Ishii, Atsushi Nakagawa, Nobuhiro Yamaguchi, Makoto Hibino, Kenji Tsushima, Tatsuya Nagai, Satoru Ishikawa, Nobuhisa Ishikawa, Yasuhiro Kondoh, Yoshitaka Yamazaki, Kyoko Gocho, Tomotaka Nishizawa, Akifumi Tsuzuku, Kazuma Yagi, Yuichiro Shindo, Yuriko Takeda, Takeharu Yamanaka, Takashi Ogura. Corticosteroids for hospitalized patients with mild to critically-ill COVID-19: a multicenter, retrospective, propensity score-matched study. Sci Rep. 2021; 11: 10727. Published online 2021 May 21.
  • Takatomo Hirouchi, Shinichiro Ota, Dai Mashima, Ryuichi Boku, Yuto Yoshida, Koki Iwata, Kanako Shinada, Takashi Matsumoto, Miwa Morikawa, Takashi Sato, Masahiro Shinoda, Kenichi Kamachi, Masaharu Shinkai. A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful. J Infect Chemother. 2021 Feb; 27(2): 379–383.
  • Masahiro Shinoda, Kenichi Kamachi, Shinichiro Ota, Lynn Yoshimatsu, Ryuichi Boku, Yuto Yoshida, Takatomo Hirouchi, Kanako Shinada, Takashi Sato, Miwa Morikawa, Koki Iwata, Takashi Matsumoto, Masaharu Shinkai. Two Cases of Severe COVID-19 Pneumonia Effectively Treated with Extracorporeal Membrane Oxygenation in Addition to Favipiravir and Corticosteroid. Intern Med. 2021 Jan 1; 60(1): 123–130
  • Miwa Morikawa, Masahiro Shinoda, Shinichiro Ota, Yuto Yoshida, Takatomo Hirouchi, Kanako Shinada, Osamu Sasaki, Takashi Sato, Kenichi Kamachi, Masaharu Shinkai. Clinical Features of 154 COVID-19 Patients and the Parameters for the Effective Detection of Pneumonia at the Time of the Initial Diagnosis in Japan. Intern Med. 2021 Jan 1; 60(1): 31–37.
  • Osamu Sasaki, Yozo Uriuda, Masaharu Shinkai, Hideki Sasaki. Atypical electrocardiographic findings in severe hyperkalemia with slow clinical course J Gen Fam Med. 2021 Jan; 22(1): 43–46.

2020年

  • Doi Y, Hibino M, Hase R, Yamamoto M, Kasamatsu Y, Hirose M, Mutoh Y, Homma Y, Terada M, Ogawa T, Kashizaki F, Yokoyama T, Koba H, Kasahara H, Yokota K, Kato H, Yoshida J, Kita T, Kato Y, Kamio T, Kodama N, Uchida Y, Ikeda N, Shinoda M, Nakagawa A, Nakatsumi H, Horiguchi T, Iwata M, Matsuyama A, Banno S, Koseki T, Teramachi M, Miyata M, Tajima S, Maeki T, Nakayama E, Taniguchi S, Lim CK, Saijo M, Imai T, Yoshida H, Kabata D, Shintani A, Yuzawa Y, Kondo M. A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01897-20.

2019年

  • Sugimura K, Ishii N. Esophageal Hematoma Mimicking a Large Esophageal Polyp: A Diagnostic Clue of Acquired Hemophilia A. Mayo Clin Proc. 2019 Oct;94(10):2142-2143.
  • Sugimura K, Sasaki O, Shinoda M, Kawasaki S, Shinkai M. Catamenial pneumothorax: a cause of monthly breathlessness. Lancet. 2019 Sep 14;394(10202):952.
  • Sasaki O, Sugimura K, Shinoda M, Shinkai M. Asymptomatic ceftriaxone-associated pseudolithiasis. J Gen Fam Med. 2019 Jul 12;20(5):209-212.
  • Sasaki O, Sugimura K, Shinoda M, Shinkai M. Esophagectasis Related to Rivastigmine. Intern Med. 2019 Jan 10. doi: 10.2169/internalmedicine.2137-18. [Epub ahead of print] No abstract available.